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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

Once phosphorylated the tyrosine residues of the beta subunit serve as docking sites for downstream signaling mediators including extracellular signal-regulated kinase (ERK) and the phosphatidylinositol-3-kinase (P13K) pathway [78] ( Figure 2 )

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The primary function of the tocopherol transfer protein is to maintain homeostatic control of -tocopherol concentrations in blood and other tissues, and it is also expressed in the kidney (Herrera et al., 2001)

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