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Since respiration (breathing) is key to staying alive, any combination of drugs that seriously depresses respiration should only be used in extreme circumstances in a clinical setting where the patient can be monitored continuously and with intubation available as an option by trained experienced medical professionals like anesthesiologist or emergency medical doctors

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The effect of methemoglobin formation in sickle cell disease

10.1016/j.brainres.2017.04.019 Brain Res

Most patients describe it as a small pinch

Radiation Modality Utilization and Cardiopulmonary Mortality Risk in the Elderly with Esophageal Cancer