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An excessive accumulation of ROS within the fetal membrane can lead to embrittlement and eventual rupture of the membrane structure

55,56 Its pathogenesis is highly complex, involving the interplay of factors including lipid metabolism disorders, 57 insulin resistance, 10 oxidative stress, 58 immune activation, 13 and gut microbiota dysbiosis

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Manufacturers and lactation experts recommend caution due to theoretical risks, unknown infant metabolic effects, and lack of safety data in vulnerable populations