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While significant muscle growth takes longer, the improved nitrogen retention and protein synthesis create a fuller, more dense appearance to existing muscle tissue

Ex vivo rectal tumour samples more accurately reflect the dynamic tumour microenvironment, the complex architecture of the tumour, and the inherent genetic diversity between patients and therefore, this data supports metformin as a metabolic modulator in rectal tumours

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2.6 Tumor size assessment A two-end electronic digital caliper (Switzerland) was used to measure the dimensions of the right thigh twice weekly, starting 7 days after tumor induction