Below, I will explain how GLP-1 medications work, how long-term use is evaluated, what side effects to be aware of, how nutrition supports sustainable progress, and how lasting weight maintenance is built through consistent habits
Thank you to our sponsors AG1 (Athletic Greens): Thesis: InsideTracker: Helix Sleep: Supplements from Momentous For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Assessing Health Status & Improving Vitality (00:02:51) Momentous Supplements (00:03:46) Thesis, InsideTracker, Helix Sleep (00:07:29) Lifespan: Bloodwork & Biomarkers Testing, The 4 Horseman of Disease (00:11:51) Healthspan: Functional Testing, Cognitive & Emotional States (00:13:59) Blood Testing: Best Frequency (00:16:01) DEXA Scan: Lean Mass & Fat, Bone Mineral Density & Osteoporosis (00:22:33) Bone Mineral Density & Age-Related Decline, Strength Training, Corticosteroids (00:29:24) Osteopenia & Osteoporosis Diagnosis, Strength Training (00:31:03) AG1 (Athletic Greens) (00:32:16) Back-casting: Defining Your Marginal Decade (00:38:31) All-Cause Mortality: Smoking, Strength, VO2 max (00:44:43) Attias Rule of Supplementation, Centenarian Decathlete Physical Goals (00:49:24) Importance of Exercise, Brain Health, MET hours (00:55:23) Nicotine & Cognitive Focus (01:03:12) Menstruation, PMS & Menopause (01:10:10) Hormone Replacement Therapy, Menopause & Breast Cancer Risk (01:22:06) Estrogen, Progesterone & Testosterone Therapies in Women (01:26:35) Hormone Replacement Therapy in Men, SHBG & Testosterone, Insulin (01:37:23) Clomid, Pituitary, Testosterone & Cholesterol, Anastrozole, HCG (01:47:46) Fadogia Agrestis, Supplements, Rapamycin (01:52:06) Testosterone Replacement Therapy & Fertility (01:59:26) Total Testosterone vs
Typically, injections are administered weekly for the first few months, then reduced to bi-weekly or monthly for maintenance
These include the following: Vitamin B12 helps convert food into usable cellular energy (ATP) within the mitochondria
Once exclusively a treatment for diabetes, GLP-1 drugs such as Zepbound and Wegovy, which suppress appetite and slow digestion, have become a mainstream weight-loss tool
They aim to enhance treatment precision, improve safety, and expand global adoption, addressing the growing demand for effective, targeted therapies in diabetes and obesity management and driving innovation and market growth worldwide
