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Together, these findings position DSIP as a multifunctional neuropeptide used in experimental models to investigate the integration of signaling pathways involved in sleep regulation, stress response, neuroprotection, and endocrine coordination

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Furthermore, GH replacement therapy restores the age-associated impairments in the skeletal muscle mitochondrial biogenesis, which is mainly manifested by the increased PGC1 , NRF1 , cytochrome c expression, and citrate synthase enzymatic activity ( On the other hand, some different views concerning the effects of GH on mitochondrial biogenesis have also been discovered

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