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"Stimulating GLP-1 receptors in the colon may simply [trigger more fluid secretion] in some people." Loss of appetite or feeling full quickly: This is part of how GLP-1 drugs promote weight loss they make it easier to eat less

JAMA Netw Open 2022;5:E221169

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Patil SP, Ayappa IA, Caples SM, Kimoff RJ, Patel SR, Harrod CG

Retatrutide is currently in Phase 3 clinical trials with FDA approval expected in 2025-2026