A reduction in CRP has been linked to a lower risk of heart disease, stroke, and metabolic disorders such as insulin resistance and type 2 diabetes
52,53 In a phase 2, multi-center trial conducted at 45 centers, orforglipron at doses of 12 mg or greater showed significant reductions in HbA1c and bodyweight compared with placebo or dulaglutide
If a patient had both obesity and type 2 diabetes, their GLP-1 prescription might still be covered under the diabetes diagnosis, though many plans implemented stricter documentation requirements to verify the primary treatment purpose
Methods 14 , 331332 (2017)
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Both are manageable