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Systemic vascular structure and function Though it remains unclear whether reductions in CBF or cerebral metabolism occurs first in the ADRD cascade, mechanical factors such as systemic and cerebral arterial stiffening are additional early stage vascular markers implicated in cerebral hypoperfusion in older adulthood beyond the typical effects of aging (Mitchell, 2011

By increasing the expression of hepcidin or suppressing FPN, IL-6 raises intracellular free iron levels, amplifying lipid peroxidation under iron-rich conditions and heightening ferroptosis (40)

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BCBSA provides health care insights through The Health of America Report series and the national BCBS Health Index SM

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