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Liver-derived FGF21 participates in GCGR mAb-induced beta cell regeneration in vivo Liver is the main source for the circulating FGF21 pool

Tirzepatide (Mounjaro, Zepbound), a dual GIP/GLP-1 receptor agonist, is substantially eliminated from the body within 23 weeks of discontinuation

Cysteine sulfenylation directs IRE-1 to activate the SKN-1/Nrf2 antioxidant response

The fluid path goes directly from barrel to needle with no expansion chamber to trap residual medication