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GLP-1 maintenance means staying on a stable, clinically effective dose after youve reached your weight-loss or metabolic health goals, says Dr

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SURMOUNT-5 was a 72-week, open-label, Phase 3b randomised trial of 751 adults with obesity but without diabetes, comparing maximum-tolerated tirzepatide (10 or 15 mg) against maximum-tolerated semaglutide (1.7 or 2.4 mg)

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This phenomenon may be partly explained by biological differences such as variations in sex hormone levels, pancreatic -cell composition, and gene expression patterns related to insulin secretion and glucose metabolism [49]