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However, like other highly effective glucose-lowering medications, rapid improvements in blood sugar control can temporarily worsen existing retinopathy in susceptible individuals

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Additional Contrave warnings Contrave has a black box warning

In June 2025, the World Health Organization warned that semaglutide drugs including Ozempic, Wegovy, and Rybelsus may rarely cause NAION

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Critically, this does not affect the glucagon response to hypoglycemia as this effect is also glucose-dependent