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Pyruvate dehydrogenase (PDH), the rate-limiting enzyme catalyzing pyruvate's oxidative decarboxylation to acetyl-CoA, is critical for lactate's irreversible clearance

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Current FDA-approved uses for semaglutide include : Type 2 diabetes management (glycemic control) Cardiovascular risk reduction in type 2 diabetes with established CVD (Ozempic) Cardiovascular risk reduction in adults with established CVD and obesity/overweight (Wegovy) Chronic weight management in obesity or overweight with comorbidities Clinicians should prescribe semaglutide according to FDA-approved indications and established clinical guidelines, including those from the American Diabetes Association (ADA) and American College of Physicians (ACP)