tirzepatide once weekly for the treatment of obesity journal club Obesity: “Mounting” Evidence for Substantial Weight Loss Effect of Tirzepatide on Maintenance

Safety Considerations and Ongoing Lipid Monitoring GLP-1 medications are generally safe for patients with elevated cholesterol, including those on concurrent statin therapy

As Mounjaro is off-label for weight loss, its long-term effects and cost implications merit careful consideration

In the SURMOUNT-1 clinical trial, patients on the 15 mg dose lost an average of 22.5% of their body weight about 48 pounds over 72 weeks

Conversely, stressed or dying chondrocytes release DAMPs, apoptotic bodies, cartilage fragments, and pro-inflammatory mediators that further activate synovial macrophages and fibroblasts, maintaining a chronic synovitic state and perpetuating pain and swelling (Fan et al., 2024

Many men with hypertension or heart failure the same conditions for which lisinopril is prescribed are also taking other medicines with stronger associations with gynaecomastia

Currently, several therapies are emerging and undergoing trials in animal models