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In biochemistry, thiol-metal coordination is well established for copper, zinc, mercury, and cadmium

An altered intestinal barrier function can also be a result of host physiological factors (e.g., bile acids) and environmental factors (e.g., dietary components) and is not necessarily deleterious, leading to a disease phenotype

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Congruently, the loss of KAT6A results in a shift in the expression of HOX genes (body segment identity), and the reduction in the expression of DLX genes (jaw and palate development) and TBX genes (heart development), among other affected genes (Voss et al, 2009, 2012

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Severyanova L, Dolgintsev ME