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Following the development of motor symptoms, cognitive dysfunctions progress due to the involvement of the atemporal cortex (Kalia 2018)

Some medications can be given this way, and some can only be given this way

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Tonelli M, Wanner C

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The core of our discussion presents a deep dive into an expanded mechanistic tapestry, where we integrate classical pathways with cutting-edge discoveries in epigenetics (e.g., protein arginine methyltransferase 5 (PRMT5) inhibition), cell death (ferroptosis), and immunomodulation