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No European Medicines Agency (EMA) marketing authorisation exists for any of these three compounds

Plain chest X-rays are unfortunately not diagnostic but may reveal decreased lung volumes, typically with prominent reticular interstitial markings near the lung bases

Neuron 103 , 820835.e7 (2019)

Left unaddressed, severe cases may progress to Barretts esophagus, a precancerous condition requiring ongoing medical surveillance