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While Dihexa-specific desensitization kinetics havent been comprehensively characterized, research on HGF and c-Met receptor signaling in other contexts indicates receptor downregulation begins within 24-48 hours of sustained agonist exposure, with maximum internalization occurring around 72 hours

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Options may include switching to a different medication such as retatrutide or semaglutide, adding a complementary medication, investigating underlying conditions more thoroughly, or considering whether the non-response is actually a medication quality issue

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