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Secondary bile acids are elevated in FM subjects compared to HC Hierarchical clustering and pairwise correlations showed strong within-class dependencies among BAs and SCFAs (i.e., metabolites clustered by biochemical subclass), in both FM and HC (Supplementary Fig

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It may influence sleep-related signaling, circadian rhythms, and stress pathways in experimental models, though findings are limited to preclinical and in vitro studies

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The mechanisms underlying these reported effects likely involve complex interactions between metabolic signaling, central reward pathways, and potentially altered taste preferences or hedonic responses to alcohol