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3.2 Potential biomarkers associated with PCa screening, early detection, and diagnosis A total of 20 potential biomarkers with possible applications in the screening, early detection, and diagnosis of PCa were identified in 13 articles from four countries ( Table 3 , Supplementary Table 3 ) (123)

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This is achieved via the increased oxygen uptake by colonocytes which then promotes epithelial hypoxia thereby supporting the anaerobic lifestyle of many important bacteria present in the intestinal mucosa (Itoh and Freter 1989

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This can lead to symptoms such as weakness, muscle cramps, irregular heartbeat, or tingling sensations