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Treatment reduces circulating markers of metabolic dysfunction and inflammation, creating a more favorable metabolic environment that supports insulin sensitivity and glucose regulation

This subsequently increased the synthesis of uridine diphosphate N-acetylglucosamine (UDP-GlcNAC), which is required for the N-glycosylation of many cell surface proteins expressed on M2 Ms (2)

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In some embodiments, the otic formulation or composition comprises about 12% by weight of the silicon dioxide

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Both components maintain stability in lyophilized form