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Separation of the parietal and chief cells using the gradient described has also been used by Noreldin et al [16]: Zhang et al [17] have also used the discontinuous iodixanol gradient strategy Use of a continuous iodixanol gradient was also reported by Singh et al [18] and by Sashidara et al [19]

Current treatments, other than insulin supplementation, are sometimes not sufficient to achieve control and may cause undesirable side effects, such as weight gain and hypoglycemia

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