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The theoretical rationale for combination therapy rests on targeting multiple neurochemical systems: GLP-1 controls homeostatic appetite, while naltrexone modulates reward-based eating behavior

Many patients mistakenly assume that refrigeration is only necessary after opening the pen

Nature 496 (7443), 101105

10.1016/j.dld.2015.07.150 209

If chills persist beyond 16 weeks or worsen over time, contact your provider to rule out other causes or discuss dose adjustments

, Phase 1 studies evaluated safety, tolerability, and pharmacokinetic characteristics Early data from Phase 2 investigations provided insights into biological activity and physiological responses