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The agency said it reviewed evidence provided by recent studies on GLP-1 drugs, in addition to unspecified clinical, nonclinical and post-marketing data

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Mechanistic studies have revealed that altered expression of iron metabolism-related proteins (including GPX4, FTH1, TfR1, and HO-1), accumulation of lipid peroxidation products, and disruption of antioxidant defense systems (particularly the Nrf2/GPX4 pathway) are central to ferroptosis progression in cardiac tissue

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Zhang, Y., Chen, Y., Wang, Y., Liu, Z., & Zhang, H

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