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Additionally, L-Carnitine: Buffers acetyl-CoA buildup during high-fat metabolism Mitigates toxic acyl-CoA accumulation in metabolic diseases Scavenges free radicals and chelates metal ions (antioxidant role) Regulates membrane fluidity and stabilizes mitochondrial membranes Modulates fatty acid oxidation enzymes via PPAR pathways Carnitine deficiency is linked to mitochondrial dysfunction, muscle weakness, and lipid accumulation

Klenotic, P

GPR40 agonists GPR40, or the FFA receptor 1, is a GPR involved in FFA-induced insulin secretion [55]

"A Bad Element"

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Key energy-related metabolites, including creatine phosphate, glucose, glucose-6-phosphate, and lactate, suggest impaired cellular energy production and storage, consistent with the reduced energy efficiency seen in GHD (42, 44)