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And small peptide GLP-1 analogues have been demonstrated to cross BBB via peripheral administration, including LG, lixisenatide and exendin-4 (72)

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[10, 19] According to ICMR data, over 135 million adults in India are affected by obesity, yet access to doctor-supervised, evidence-based metabolic and weight management including GLP-1 treatment remains limited

Researchers call these folks non-responders. In clinical trials , about 9% of people did not respond to the drug, even on the highest 15 mg dosage

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17 PPAR is mostly expressed in the adipose tissue and controls lipogenesis, adipocyte differentiation, and glucose metabolism