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This bidirectional signaling pathway connecting the gastrointestinal tract and the central nervous system involves mechanisms associated with the intestinal peptides, in particular human incretin hormones such as anorexigenic GLP-1

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10.1152/physrev.00007.2010 97 MulliganK.KhatamiH.SchwarzJ

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The initial attempts to induce DE differentiation using small-molecule cocktails containing CHIR and IDE1 (CI-I and CI) proved inefficient