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Generally, two major mechanisms can be envisioned to claim obesogens as prostate carcinogens: i) paracrine signalling by proinflammatory cyto- and chemokines produced by the adipose tissue/PPAT under obesogenic stimulation, creating a chronic inflammatory microenvironment that promotes cancer cell survival, facilitates immune evasion, and supports the spread of malignant cells to distant organs

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IGFBP-2, an important member of the insulin-like growth factor binding protein family, is able to regulate a variety of cell signaling pathways to influence tumor progression

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Ma L, Ye J, Yang Y et al (2019) The SOS2-SCaBP8 complex generates and fine-tunes an AtANN4-dependent calcium signature under salt stress

Lancet Diabetes Endocrinol 8:719