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We identified detrimental metabolic effects following either the discontinuation of GLP-1 receptor agonist therapy or its substitution with DPP4i or SGLT2i treatments

10.1006/nbdi.2001.0470 Neurobiol

The intestinal epithelium is not only a selective barrier it is also a highly active metabolic site that can influence: First-pass extraction Oral bioavailability Gut-specific drug-drug interactions Metabolite formation In vivo PK predictability Thats why intestine microsomes are increasingly being incorporated into ADME workflows when understanding presystemic metabolism and oral PK is critical.By providing access to intestinal phase I and phase II enzyme activity, including key CYP and UGT pathways, intestine microsomes help researchers better model presystemic metabolism and generate more biologically relevant in vitro data

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