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Vitamin B12 is water-soluble, meaning that excess amounts are readily excreted in the urine

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This combination of hydration and disruption of the mucin interactome sharply reduces inflammatory stresses on airway epithelia and helps to prolong cough relief, owing to the osmotic effects of the released globular proteins

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Alternatively, it may be that the in vitro neutralization assay is not fully representative of in vivo conditions, as has been described in the context of HPV infection of mice 178

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