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JAMA Dermatology, 158 (3), 266
Unlike Semaglutide (single GLP-1 agonist) or Tirzepatide (dual GIP/GLP-1 agonist), Retatrutide activates three distinct metabolic hormone receptors simultaneously
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Collectively, these findings revealed the essential physiological actions of GLP-1R and GIPR signaling for islet hormone secretion in mice and humans (5)
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