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We chose a 24 mg/kg dose in this study because our previous study has shown that this dose is the pharmacologically maximal effective dose for inhibiting cognitive decline in aged APP/PS1 mice [9]

What volume of the reconstituted tesamorelin (10 mg) solution should be drawn after adding 3 mL bacteriostatic water to achieve the desired dose?

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23% reached 30% or more

The SASP damages surrounding tissue, drives chronic inflammation, and converts neighboring healthy cells into senescent ones (van Deursen, 2014)

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