switching from dulaglutide to semaglutide No Difference Seen in Risk of Sight-threatening DR Among GLP-1 Drugs Semaglutide Shows Comparable Glycemic Control

Osmotic stress has been associated with a reduced BHMT expression such that the role of betaine in osmoregulation may be temporarily prioritized over its function as a methyl donor (2)

A small dose of niacin (2550 mg not niacinamide) can help neutralize excess methyl groups and reduce symptoms of overstimulation

10.3390/ijms26157342 27 ChenY.JiangY.YangY.HuangX.SunC

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Weight regain is common after discontinuationSTEP 1 extension data showed participants regained roughly two-thirds of lost weight within a year of stopping

This approach is designed to meet regulatory expectations and, at the same time, reduce two foreseeable risks: inadvertent early pregnancy exposure and metabolic rebound after cessation