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By maintaining balanced homocysteine levels, B12 can lower the risk of heart-related conditions

In older adults, secretion of hydrochloric acid in the stomach is reduced significantly, which can lead to poor absorption of vitamin B12

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There are various potential causes of vitamin B12 deficiency besides pernicious anemia, which gastrointestinal surgery long-term use of certain medications, such as proton pump inhibitors genetic intrinsic factor defects dietary deficiency Pernicious anemia requires lifelong treatment

Typical therapeutic doses can range from 1000 mcg once weekly to monthly