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We suspect that this dramatic rise is likely related to weight management, says Joyce Lee, a pediatrician and diabetes specialist at the University of Michigan, who led the study

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Saxagliptin has been demonstrated to improve ED by upregulating stromal cell-derived factor 1 (SDF-1), which enhances EPC homing, and by activating phosphoinositide 3-kinase/protein kinase B (PI3K)/Akt signaling, thereby diminishing oxidative stress and apoptosis [160]

[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Arnarson A, Gudny GO, Ramel A, Briem K, Jonsson PV, Thorsdottir I