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Tolerance and digestive effects Common comments include issues of gastrointestinal tolerance (discomfort, nausea, diarrhoea) and, at high doses, the possible characteristic body odour described in some sources

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Diabetes Metab Res Rev 35(7):e3168 Funding This work was supported by the French Society of Rheumatology

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Key features of PCOS include: Menstrual irregularities or absent periods (oligomenorrhoea or amenorrhoea) Clinical or biochemical signs of hyperandrogenism (excess facial or body hair, acne, male-pattern baldness) Polycystic ovarian morphology on ultrasound examination Insulin resistance and compensatory hyperinsulinaemia Diagnosis typically follows the Rotterdam criteria, requiring at least two of the first three features above, after exclusion of other endocrine disorders

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