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Post hoc adjustment for HbA1C and other traditional renal risk factors did not have a major influence on renal benefit by liraglutide, semaglutide, or dulaglutide in CVOTs, nor were there differences in glycemic control in the AWARD-766 study

Dose: 5mg subcutaneous injection weekly Expected side effects: Moderate nausea (55-65% of users), appetite significantly reduced, possible constipation or diarrhea Expected weight loss: 5-8 pounds cumulative (8-13 pounds total since start) Critical actions: Implement anti-nausea strategies, maintain protein despite reduced appetite, begin light exercise if tolerated Cold foods become essential during this phase

Eur J Clin Pharmacol 2005;61:567-72

Retatrutide and tirzepatide are often compared because they represent the next wave of metabolic medications, but theyre not equally accessible

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Medicine and Science in Sports and Exercise