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My initial interest in this was to see if there was any support for an SMVT defect in pantothenic acid transport on the Vibrant panel

The REDEFINE 2 trial examined the combination in adults with type 2 diabetes, where weight loss is typically harder to achieve due to insulin resistance and medication effects

That's a substantial amount of time

Clinical trials show that 4-week GLP-1 treatment produces weight loss, but studies lasting 12-52 weeks demonstrate that sustained therapy achieves 15-22% body weight reduction compared to 5-8% in the first month

Six months after her initial presentation, her weakness continued to persist, and the patient remained primarily bedbound

But I also think that in the wake of blockbuster drugs, were going to continue to have this conversation around when and where its prudent to cover these medications