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People with treatment-resistant hypertension, especially those with co-existing diabetes, obesity, heart failure (HF), or chronic kidney disease (CKD) may particularly benefit from SGLT2-i and GLP-1RA

Semaglutide alleviates gut microbiota dysbiosis induced by a high-fat diet

Another exciting avenue is the development of small-molecule GLP-1RAs, designed for oral delivery

Clinical research shows that these medications reduce caloric intake by up to 39%

Case reports and observational commentary suggest monitoring may be reasonable in long-duration therapy, particularly when intake is reduced

Maintain hydration with adequate fluid intake