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However, researchers estimate that the lethal dose of GHK-Cu would be about 330 mg/kg of body weight, which is over 300 times larger than its known effective dose

Pharmaceutical GLP-1 receptor agonists are licensed for type 2 diabetes and specific obesity indications according to NICE guidance, requiring GP consultation and monitoring

For example, angina, which is chest pain due to reduced blood flow to the heart, can sometimes be accompanied by unusual sensations, including coldness, though this is less typical