This secretion is enhanced by increased Ca 2+ influx due to several PKA- and EPAC-dependent mechanisms: (1) the inhibition of ATP-regulated K + ion channels, (2) an increase in activity of L-type voltage-gated Ca 2+ channels (VGCCs), and (3) triggering the opening of non-specific cation channels [18,19,20,21]
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Bonsignore A, Cancedda R, Nicolini A, Damiani G, Deflora A