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The mean age group affected are in their 3rd and 4th decade of life and there seems to be a predilection for females

Those with active nutritional deficiencies should have these corrected before starting therapy

The discovery of sodium-channel block as the major mechanism underlying antiarrhythmic effects of quinidine led to the development of class I antiarrhythmic agents such as flecainide and propafenone

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Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions