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Historical Development of Matrices In MALDI-MS, the matrix is an organic or inorganic compound that is added in large or excess amounts to the target sample or analytes

Jumping straight to a high dose is a recipe for severe nausea, vomiting, and potentially abandoning the protocol altogether

In the case of chronic illness, this is a maintenance supplement

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Although we felt the homogenization method may be acceptable for labs with the facilities to make the particles and that these experiments allowed us to optimize the parameters necessary for protein purification, we felt that further improvements were possible