In conclusion, we propose a model (Figure 5) in which basic lipophilic compounds accumulate in lysosomes and not only induce cell death due to lysosome membrane permeablization at higher concentrations, but also perturb autophagy process as a result of lysosomal dysfunction at relatively lower concentrations
Third, residual confounding from unmeasured factors such as smoking status, alcohol intake, family history of cancer, and dietary patterns may have influenced the observed associations but could not be adjusted for in this aggregate-level analysis
Candidates typically have insulin resistance, excess body fat, metabolic dysfunction, or weight that has become resistant to traditional efforts
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ACPs have gained attention for their potential in cancer imaging, a targeted therapy approach
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