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Upon binding, the receptor-ligand complex initiates intracellular signaling cascades involving pathways such as phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt), as well as mitogen-activated protein kinase (MAPK) signaling

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Previous work from our group supports the importance of arterial stiffness as an early-stage biomarker for future decrements in brain structure by showing that high levels of arterial stiffness in midlife, but not age-related arterial stiffening, are predictive of lower grey matter volume and greater white matter hyperintensity burden in a 10-year follow-up (Bown et al., 2021), all of which are brain regions that are highly vulnerable to neurodegeneration (Fjell et al., 2014)

10.1155/2016/5646384 33 FengY.YuZ.TangM.LiJ.PengB.JuaitiM.et al (2024)