GLP-1 and GLP-1RAs promote the expansion of -cell mass by stimulating -cell proliferation, inducing islet neogenesis, and inhibiting -cell apoptosis (Wajchenberg, 2007)
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In a study published in The Journal of Clinical Endocrinology & Metabolism , children who were given a Sermorelin injection daily had boosted growth hormone levels by 74% in six months: The efficacy and safety of 1 yr of GH-releasing hormone [GHRH-(1-29)] therapy in GH-deficient children were determined
In this regard, Figure 2 depicts how GLP-1 RAs engage the GLP-1 receptor to modulate multiple hallmarks of aging
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