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However, in CY 2027 and later years of Table 166 of this final rule with comment period, the savings estimates also include the impact of this policy on reducing Medicare Advantage payments starting in CY 2027, and this is why the estimates in Table 111 of the CY 2026 OPPS/ASC proposed rule were greater than the commenter's estimates beginning in CY 2027

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One works through a validated biological mechanism

Fan Y-Y, Davidson LA, Callaway ES et al (2015) A bioassay to measure energy metabolism in mouse colonic crypts, organoids, and sorted stem cells