Glucagon-like peptide-1 (GLP-1) mimetics are a class of recently developed diabetes therapy that do not lead to hypoglycemic, but some reports have suggested a relationship between GLP-1 mimetics and ketogenesis
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TRT may also slightly improve baseline metabolic rate, which can enhance the weight loss response to GLP-1 agents by 510% in some studies, though individual variation is substantial
The role of other factors in pathomechanism of IR is also under investigation