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Community protocols hold each step at least 4 weeks and step back if a compound can't be tolerated

Three research contexts recur in the literature

Once the pen is used for the first time, it should be used within 28 days, whether it is kept at room temperature or in the refrigerator

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Prevent this by avoiding fatty foods and acidic foods (coffee, citrus products, chocolate, red meat, wine, etc.) and avoid eating and reclining immediately

Subramaniam and Fletcher, 2018)