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GLP-1, secreted by the intestine, brainstem, and pancreas, also exerts appetite-suppressing and gastric emptying-delaying effects on the hypothalamus

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Although anxiety and depression are complex disorders with diverse biological and psychological characteristics, animal models can replicate certain aspects of these conditions, including neurochemical mechanisms, with repercussions on social and cognitive domains, providing a valuable framework for testing new therapeutic strategies [43, 44]